BLOODHOUND, the successor of Thrust SSC which was the first supersonic car in the world, uses topology optimization to design its structure. In their website, it is stated that stiffness is the main design criteria for the body so it seems they naturally chose topology optimization to find the optimum structure. The design space was denoted by a shell structure and two load cases were used (bending and torsion)
[youtube=http://www.youtube.com/watch?v=pvsA0JU33cg&feature=player_embedded]